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目的:观察半量激素联合霉酚酸酯(MMF)治疗扁桃体摘除术后IgA肾病的疗效及安全性。方法:选取我院经肾活检确诊IgA肾病患者共207例,分为手术组及对照组,2组均给予半量激素联合MMF,随访时间为1a。观察2组蛋白尿水平、红细胞数量及血压、肾功能情况变化。结果:2组服药治疗3个月后,尿红细胞、尿蛋白定量均好转,且手术组优于对照组(P<0.05);手术组血压、内生肌酐清除率及对照组血压无明显变化,但对照组内生肌酐清除率下降(P<0.05)。结论:半量激素联合MMF治疗扁桃体摘除术后IgA肾病疗效肯定,对肾功能有保护作用。
Objective: To observe the efficacy and safety of semi-hormones combined with mycophenolate mofetil (MMF) in the treatment of IgA nephropathy after tonsillectomy. Methods: A total of 207 patients with IgA nephropathy diagnosed by renal biopsy in our hospital were divided into operation group and control group. Both groups were given MMF combined with MMF for a follow-up of 1a. The levels of albuminuria, erythrocyte number, blood pressure and renal function were observed. Results: After three months of treatment, the urinary erythrocytes and urinary protein were all improved in both groups, and the surgery group was better than the control group (P <0.05). The blood pressure, endogenous creatinine clearance rate and blood pressure of the control group did not change significantly, However, the creatinine clearance in the control group decreased (P <0.05). Conclusion: The combination of semi-hormones and MMF is effective in treating IgA nephropathy after tonsillectomy and has a protective effect on renal function.