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目的:在MPP患儿急性期对心肌损害标志物进行检测,以观察其变化规律及探讨临床价值。方法:以MPP患儿为测量组,同期体检健康儿童为对照组,测量两组在心肌酶谱、肌红蛋白(MB)、肌钙蛋白(cTnI)、糖原磷酸化酶同工酶BB(GPBB)方面上的变化。结果:观察指标AST、LDH、a-HBDH、CK方面测量组与对照组相比明显增高,差异有统计学意义(P<0.01),CK-MB增高差异有统计学意义(P<0.05);MB测量组与对照组相比差异有统计学意义(P<0.01);测量组与对照组在cTnl、GPBB上差异有统计学意义(P<0.05)。结论:观察MPP急性期患儿心肌损伤标志物的变化对于判断疾病合并症及引起多脏器功能损伤具有重要的意义,值得临床重视研究。
OBJECTIVE: To detect the markers of myocardial damage in the acute phase of MPP in order to observe the changes and to explore the clinical value. Methods: The children with MPP as the measurement group and the healthy children during the same period were taken as the control group. The myocardial enzymes, myoglobin (MB), troponin (cTnI), glycogen phosphorylase isoenzyme BB GPBB) aspects of the change. Results: Compared with the control group, the indexes of AST, LDH, a-HBDH and CK in observation group were significantly higher than those in control group (P <0.01). The difference of CK-MB was statistically significant (P <0.05). The difference between MB measurement group and control group was statistically significant (P <0.01). The difference between cTnl and GPBB in measurement group and control group was statistically significant (P <0.05). CONCLUSION: It is of great significance to observe the changes of myocardial injury markers in children with acute MPP in judging the comorbidity of diseases and causing the multiple organ dysfunction. It is worth studying clinically.