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目的:分析异位妊娠(EP)患者早期诊断中对血浆血管内皮生长因子(VEGF)测定的临床意义,为临床诊断提供参考。方法:选取2012年1月~2013年12月期间该院接受治疗并确诊的78例EP患者作为观察组,选择同期在该院门诊的78例正常宫内妊娠妇女作为对照组。血浆VEGF应用酶联免疫吸附试验(ELISA)进行测定;采用放射免疫法检测血浆孕酮(P)含量。结果:观察组测定P值(6.84±12.34)ng/ml显著低于对照组(27.35±12.06)ng/ml,且差异有统计学意义(P<0.05);观察组测定VEGF值(95.38±67.49)pg/ml显著高于对照组(17.37±11.57)pg/ml,且差异有统计学意义(P<0.05);以血浆P值62 nmol/L为截断点,诊断EP的灵敏度为96.25%,特异度为73.16%;以血浆VEGF值238 pg/ml为截断点,诊断EP的灵敏度为83.49%,特异度为91.58%。结论:EP早期诊断中可将血浆VEGF含量作为新的一种辅助生化指标,该项指标是了解患者病情及判断预后的指标之一,对于临床早期诊断EP具有重要研究价值,值得进一步应用。
Objective: To analyze the clinical significance of plasma vascular endothelial growth factor (VEGF) in the early diagnosis of patients with ectopic pregnancy (EP) and provide reference for clinical diagnosis. Methods: From January 2012 to December 2013, 78 cases of EP patients who were treated and confirmed in the hospital were selected as the observation group and 78 normal pregnant women in the same period were selected as the control group. Plasma VEGF levels were measured by enzyme-linked immunosorbent assay (ELISA). Plasma progesterone (P) levels were measured by radioimmunoassay. Results: The P value in the observation group was significantly lower than that in the control group (6.84 ± 12.34 ng / ml vs 27.35 ± 12.06 ng / ml, P <0.05), and the VEGF value in the observation group was 95.38 ± 67.49 ) pg / ml was significantly higher than that of the control group (17.37 ± 11.57) pg / ml, and the difference was statistically significant (P <0.05); the sensitivity of EP was 96.25% when the plasma P value was 62 nmol / The specificity was 73.16%. The sensitivity and specificity of EP with 238.49 μg / ml VEGF as the cut-off point were 83.49% and 91.58% respectively. Conclusion: Plasma VEGF level can be used as a new auxiliary biochemical index in the early diagnosis of EP. This index is one of the indicators to understand the patient’s condition and prognosis. It is of great value for early clinical diagnosis of EP and should be further applied.