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目的:观察门冬氨酸鸟氨酸与乳果糖联合治疗肝性脑病的临床疗效及护理方法。方法:62例肝性脑病患者随机分为治疗组和对照组,治疗组予门冬氨酸鸟氨酸静滴,口服乳果糖加上综合治疗,对照组仅给予综合治疗。观察治疗前后两组肝功能(总胆红素、转氨酶)及血氨值的变化;比较两组总有效率。结果:治疗组改善肝功能及降低血氨明显优于对照组(P<0.05);治疗组对照组总有效率分别为87.1%和61.3%,差异有统计学意义(P<0.05)。结论:门冬氨酸鸟氨酸与乳果糖联合治疗肝性脑病疗效显著,无明显不良反应,值得临床推广。
Objective: To observe the clinical efficacy and nursing of combined treatment of aspartate ornithine and lactulose in hepatic encephalopathy. Methods: Sixty-two patients with hepatic encephalopathy were randomly divided into treatment group and control group. The treatment group was treated with ornithine aspartate and oral lactulose combined with comprehensive treatment. The control group was given only combined treatment. The changes of liver function (total bilirubin and aminotransferase) and blood ammonia level were observed before and after treatment. The total effective rate was compared between the two groups. Results: The treatment group improved liver function and blood ammonia significantly better than the control group (P <0.05). The total effective rate of the control group was 87.1% and 61.3% respectively, with statistical significance (P <0.05). Conclusion: Aspartic acid ornithine combined with lactulose treatment of hepatic encephalopathy significant effect, no significant adverse reactions, is worth clinical promotion.