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目的探讨联合测定患者血清和胸水中糖类抗原(CA125、CA199、CA153)和癌胚抗原(CEA)对肺癌的诊断价值。方法采用化学发光免疫法测定68例肺癌患者和38例肺结核患者血清以及胸水中CA125、CA199、CA153和CEA的含量。结果肺癌组患者血清中CEA、CA199、CA153的含量均明显增高且明显高于肺结核组患者血清中CEA、CA199、CA153的含量,有显著性差异(P<0.01)。而肺癌组患者和肺结核组患者血清中CA125的含量均明显增高,无显著性差异(P>0.05)。肺癌组患者胸水中CEA、CA125、CA199、CA153的含量均明显增高且明显高于肺结核组患者胸水中CEA、CA125、CA199、CA153的含量,CEA有显著性差异(P<0.01),CA125、CA199、CA153有显著性差异(P<0.05)。结论 CEA、CA125、CA199、CA153的血清和胸水联合检测可以提高肺癌诊断水平。
Objective To investigate the diagnostic value of combined detection of carbohydrate antigen (CA125, CA199, CA153) and carcinoembryonic antigen (CEA) in serum and pleural fluid of patients with lung cancer. Methods The levels of CA125, CA199, CA153 and CEA in serum and pleural effusion of 68 patients with lung cancer and 38 patients with pulmonary tuberculosis were determined by chemiluminescence immunoassay. Results The serum levels of CEA, CA199 and CA153 in patients with lung cancer were significantly higher than those in patients with pulmonary tuberculosis (P <0.01). The levels of CEA, CA199 and CA153 in patients with pulmonary tuberculosis were significantly higher than those in patients with pulmonary tuberculosis. The serum CA125 levels in patients with lung cancer and pulmonary tuberculosis patients were significantly increased, no significant difference (P> 0.05). The levels of CEA, CA125, CA199 and CA153 in pleural effusion of patients with lung cancer were significantly higher than those of patients with pulmonary tuberculosis, the contents of CEA, CA125, CA199 and CA153 in pleural effusion of patients with lung cancer were significantly higher than that of CEA (P <0.01) , CA153 had significant difference (P <0.05). Conclusions The combined detection of CEA, CA125, CA199 and CA153 serum and pleural fluid can improve the diagnosis of lung cancer.