【摘 要】
：
In the present study, a rat model of non-traumatic intracerebral hemorrhage was established by type IV collagenase injection into the right globus pallidus. Bax
【机 构】
：
Department of Neurosurgery, Second Affiliated Hospital, Medical School of Xi’an Jiaotong University,
论文部分内容阅读
In the present study, a rat model of non-traumatic intracerebral hemorrhage was established by type IV collagenase injection into the right globus pallidus. Bax and Bcl-2 expression in tissues surrounding hematomas was significantly increased within 14 days after injury, and it then gradually decreased. Vascular endothelial growth factor, Flk-1 and Flt-1 mRNA expression gradually increased over time. After intraperitoneal injection with minocycline, Bax expression was decreased 1 day after intracerebral hemorrhage. Flk-1 and Flt-1 mRNA expression was decreased after minocycline injection, but Bcl-2 expression was increased, and vascular endothelial growth factor mRNA expression was decreased between 4-14 days. These results indicated that protective effects of minocycline on nerve tissues were associated with increased Bcl-2 expression and decreased Bax expression in the early stage after intracerebral hemorrhage. In the late stage, minocycline downregulated vascular endothelial growth factor and its receptor expression to inhibit brain tissue self-repair.
其他文献
目的 对应用综合护理模式对糖尿病酮症酸中毒患者实施护理的效果进行研究.方法 将84例糖尿病酮症酸中毒者分成对照组和观察组,每组42例.分别实施常规护理和综合护理.结果 观
目的:探讨解剖钢板植骨或不植骨治疗跟骨骨折疗效比较.方法:随机抽取150例进行解剖钢板植骨或不植骨治疗跟骨骨折治疗的患者作为研究对象,其中75例患者作为对照组进行研究,75
Rats with chronic pilocarpine-induced temporal lobe epilepsy complicated with depression were studied. Anti-5-bromodeoxyuridine immunofluorescence staining and
Three cycles of remote ischemic pre-conditioning induced by temporarily occluding the bilateral femoral arteries (10 minutes) prior to 10 minutes of reperfusion
目前虽然对以血浆肾素活性(PRA)或血管紧张素Ⅱ(ATⅡ)水平作为原发性高血压病肾素分型的临床意义尚有争论,且多持否定意见,但二者仍为反映病程的
Although the clinical si
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生、测量监控等方面人手,介绍了S226海滨大桥
贫血的定义循环血液中的红细胞数或血红蛋白含量低于正常时称为贫血。国内一般认为,成年男性少于400万/立方毫米,血红蛋白含量低于12克%;成年女性红细胞少于350万/立方毫米,
教学的本质是一种精神的感染,是一种科学的引领。成功的教学是一种艺术的传递,是一种轻松的合作,是一种快乐的创造。正如捷克教育家夸美纽斯所畅言:“教育者的艺术表现在使学
Animal models of intracerebral hemorrhage were established by injection of autologous blood into the caudate nucleus in rats. Cell apoptosis was measured by flo
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生、测量监控等方面人手,介绍了S226海滨大桥