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美尼氏病的病因还不清楚,有人提出水与电解质交换障碍引起内淋巴积水的假说。著者考虑锂游子可以影响内淋巴间隙中水和电解质的交换,因此采用碳酸锂治疗此病,收到一定效果。碳酸锂每片含300毫克,每晚服600—900毫克(即2—8片),服药后12小时血清锂浓度0.7—1.3毫克分子量/公升。由于锂剂有副反应,如血清浓度超过1.3毫克分子量/公升,多数病人可发生毒性反应如噁心、呕吐、腹泻、震颤、疲倦及思睡等;如浓度超过2.0毫克分子量/公升,这些症状就会加重,并可出现大脑症状,甚至致死。不过如细心给药,可得到有效和安全的结果。
The etiology of Meniere’s disease is unclear, and the hypothesis that water and electrolyte exchange disorders cause endolymphatic hydrops. The authors consider lithium Youzi can affect the endolymph interstitial water and electrolyte exchange, so the use of lithium carbonate to treat the disease, received some results. Lithium carbonate contains 300 mg per tablet, 600-900 mg per night (ie 2-8 tablets), and a serum lithium concentration of 0.7-1.3 mg / l at 12 hours after treatment. Due to side effects of the lithium agent, such as serum concentration exceeds 1.3 mg / l, most patients may develop toxic reactions such as nausea, vomiting, diarrhea, tremors, tiredness and sleepiness; if the concentration exceeds 2.0 mg / l, these symptoms Will aggravate, and may have brain symptoms, or even death. However, if carefully administered, can be effective and safe results.