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目的:探讨吉西他滨、顺铂、泼尼松组成的GDP方案治疗复发难治性非霍奇金淋巴瘤的疗效和毒副反应。方法:GDP方案:吉西他滨1000mg/m2,加入生理盐水100mL中,静脉滴入(≥30min),d1、d8;DDP25mg/m2,静脉滴入,适当水化,d1～d3;PDN50mg/d,口服,d1～d10,21d为1个周期。全组32例患者接受1～6个周期化疗,平均2.7个周期。结果:27例患者完全缓解6例(22.22%),部分缓解11例(40.74%),总有效率62.96%。毒副反应主要为骨髓抑制,尤其血小板下降,Ⅲ～Ⅳ度血小板下降占全组29.63%。无治疗相关死亡。结论:GDP方案是治疗复发难治性非霍奇金淋巴瘤的一个有效方案,毒副反应可以耐受。
Objective: To investigate the efficacy and side effects of GDP regimen consisting of gemcitabine, cisplatin and prednisone in the treatment of relapsed and refractory non-Hodgkin’s lymphoma. Methods: GDP program: gemcitabine 1000mg / m2, adding saline 100mL, intravenous infusion (≥ 30min), d1, d8; DDP25mg / m2, intravenous infusion, appropriate hydration, d1 ~ d3; PDN50mg / d, d1 ~ d10, 21d for a period. The whole group of 32 patients received 1 to 6 cycles of chemotherapy, an average of 2.7 cycles. Results: Twenty-seven patients achieved complete remission in 6 cases (22.22%), partial remission in 11 cases (40.74%) and total effective rate of 62.96%. The main side effects were myelosuppression, especially thrombocytopenia, Ⅲ ~ Ⅳ thrombocytopenia accounted for 29.63% of the whole group. No treatment-related deaths. Conclusion: The GDP regimen is an effective treatment for relapsed and refractory non-Hodgkin’s lymphoma. Toxicity and side effects can be tolerated.