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目的分析、研究在卵巢癌组织中促癌基因C-erb B-2与肝素结合样表皮生长因子(HB-EGF)的表达情况及临床意义。方法以正定县人民医院2014年3月-2016年12月期间行卵巢肿瘤手术的75例患者为研究对象,将其中上皮性卵巢癌患者设为卵巢癌组,交界性卵巢瘤患者设为交界组,良性卵巢瘤患者设为良性组,每组各25例,取所有对象的卵巢组织进行检测,对比分析组织中C-erb B-2、HB-EGF的表达情况。结果卵巢癌组C-erb B-2、HB-EGF阳性细胞率及平均荧光强度较之良性组及交界组均显著升高,组间比较差异有统计学意义(P<0.05),且C-erb B-2、HB-EGF在卵巢癌Ⅲ~Ⅳ期组织中表达高于Ⅰ~Ⅱ期(P<0.05)。结论 C-erb B-2、HB-EGF参与卵巢癌的发生发展当中,且与病情严重程度呈正相关关系,二者可以作为卵巢良恶性肿瘤鉴别诊断的辅助指标,二者联合检测可以更准确反映卵巢癌病情。
Objective To analyze the expression of C-erb B-2 and heparin-binding epidermal growth factor (HB-EGF) in ovarian cancer and its clinical significance. Methods Totally 75 patients with Ovarian tumor surgery from March 2014 to December 2016 in Zhengding County People’s Hospital were selected as ovarian cancer patients and ovarian cancer patients with borderline ovarian cancer , Benign ovarian tumor patients were set as benign group, 25 cases in each group. All the ovarian tissues of all the subjects were detected, and the expression of C-erb B-2 and HB-EGF in the tissues were compared. Results The positive rate of C-erb B-2 and HB-EGF in ovarian cancer group was significantly higher than that in benign group and junctional group (P <0.05), and the positive rate of C- The expression of erb B-2 and HB-EGF in stage Ⅲ ~ Ⅳ ovarian cancer tissues was higher than that in stage Ⅰ ~ Ⅱ stage (P <0.05). Conclusions C-erb B-2 and HB-EGF are involved in the occurrence and development of ovarian cancer and have a positive correlation with the severity of the disease, both of which can be used as auxiliary indicators for the differential diagnosis of benign and malignant ovarian tumors. The combined detection of C-erb B-2 and HB-EGF can reflect more accurately Ovarian cancer condition.