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卵巢上皮性癌是死亡率最高的妇科恶性肿瘤。临床常用的治疗方案是理想的初次肿瘤细胞减灭术及术后辅以铂类+紫杉醇为基础的系统化疗。对晚期不能切除的卵巢癌,新辅助化疗能降低肿瘤负荷,提高手术切除的彻底性,是一种新的治疗策略。本文就新辅助化疗在卵巢癌治疗中的概念、目的、病例选择标准、术前选择新辅助化疗的评估方法、化疗方案、疗程、给药途径,疗效评价及临床价值等进行综述。
Epithelial ovarian cancer is the highest mortality of gynecological malignancies. Commonly used in clinical treatment is the ideal initial cytoreductive surgery and postoperative adjuvant platinum + paclitaxel-based systemic chemotherapy. For advanced unresectable ovarian cancer, neoadjuvant chemotherapy can reduce tumor burden and improve the thoroughness of resection, which is a new treatment strategy. This review summarizes the concept, purpose, criteria of case selection, preoperative selection of neoadjuvant chemotherapy, chemotherapy regimen, course of treatment, route of administration, efficacy evaluation and clinical value of neoadjuvant chemotherapy in the treatment of ovarian cancer.