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目的探讨米非司酮联合甲基睾丸素治疗近绝经期子宫肌瘤的临床效果。方法将近绝经期子宫肌瘤伴有不规则阴道流血的患者162例随机分成两组,A组:米非司酮组,81例,每日口服米非司酮10mg,连服3mo。B组:米非司酮配伍甲基睾丸素组,81例,每日口服米非司酮10mg,连服3mo,同时口服甲基睾丸素5mg,1次/d,连服6mo。全部贫血病例辅以硫酸亚铁、维生素C治疗。治疗前和服药6mo后1wk内由专人B超测量子宫及子宫肌瘤三维径线,同时予清宫并行子宫内膜病检。服药前及停药后1wk内测血红蛋白、肝肾功能,并记录服药期间的不良反应。结果两组患者治疗期间均闭经。两组治疗后,子宫体积最大肌瘤体积缩小,血红蛋白上升。治疗后A组35.8%进入绝经期,B组75.3%进入绝经期。治疗后两组之间差异有显著性(P<0.01)。两组不良反应类似且无需特殊处理。结论米非司酮联合小剂量甲基睾丸素治疗近绝经期子宫肌瘤是比较理想的治疗方法。
Objective To investigate the clinical efficacy of mifepristone combined with methyltestosterone in the treatment of uterine fibroids in near menopause. Methods A total of 162 patients with uterine leiomyoma with irregular vaginal bleeding were randomly divided into two groups. Group A: Mifepristone group, 81 cases. Oral mifepristone 10 mg daily for 3 months. Group B: mifepristone with methyltestosterone group, 81 cases, daily oral mifepristone 10mg, and even served 3mo, while oral methyltestosterone 5mg, 1 / d, and even served 6mo. All cases of anemia supplemented by ferrous sulfate, vitamin C treatment. Before treatment and medication within 1wk after 6mo measured by special B-uterine and uterine fibroids three-dimensional line, at the same time to Qing Gong parallel endometriosis. Before taking and after stopping 1wk measured hemoglobin, liver and kidney function, and record the adverse reactions during the medication. Results Both groups were amenorrhea during the treatment. After treatment, the volume of the uterine fibroids shrinks and hemoglobin rises. After treatment, 35.8% of A group entered menopause, and 75.3% of B group entered menopause. After treatment, the difference between the two groups was significant (P <0.01). The two groups had similar adverse reactions and no special treatment was required. Conclusion Mifepristone combined with low-dose methyltestosterone in the treatment of proximal uterine fibroids is an ideal treatment.