本文用~3H-咖啡酸给小白鼠静脉注射196μci/鼠的大剂量,按不同时间进行整体放射自显影切片,经125天曝光显影,用普通X光片获得一系列较为清晰明辨的自显影图片,材料易得,方法可行。图片揭示出咖啡酸在体内快速选择性地分布在肝、肾、脾、肺、垂体、骨髓及胸腺等脏器组织,虽经胆汁迅速排泌,但因肠—肝循环,主要仍自肾脏迅速排泄。此种选择性分布可能与其止血、升白、利胆、保肝等药效有一定关系。 In this paper, ~ 3H-caffeic acid to mice intravenous injection of large doses of 196μci / mouse, according to the time of the whole autoradiography, after 125 days exposure to development, with a series of X-ray to obtain a more clear self-imaging Pictures, materials, easy to get, the method is feasible. The picture shows that caffeic acid is rapidly and selectively distributed in the body in the liver, kidney, spleen, lung, pituitary, bone marrow and thymus and other organs and tissues, although bile excretion quickly, but due to the intestine - liver circulation, mainly from the kidney rapidly excretion. This selective distribution may be related to its hemostasis, white, gallbladder, liver and other pharmacological effects.