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目的研究血清组织蛋白酶X(Cathepsin X,Cat X)在食管鳞癌中的临床意义。方法应用酶联免疫吸附技术(enzyme linked immunosorbent assay,ELISA)检测65例食管鳞癌患者、35例健康体检者中血清Cat X的含量,分析血清Cat X的表达水平与食管鳞癌患者临床病理特征之间的关系。结果食管鳞癌患者血清Cathepsin X水平明显高于健康体检者(P<0.01),食管鳞癌患者血清Cathepsin X水平的高低与食管鳞癌的分期、淋巴结转移情况显著相关(P<0.05)。结论血清Cat X可能成为一种新的肿瘤标志物,有助于食管鳞癌的早期诊断、预后预测,以及侵袭转移情况的判断。
Objective To study the clinical significance of serum Cathepsin X (Cat X) in esophageal squamous cell carcinoma. Methods The serum levels of Cat X in 65 esophageal squamous cell carcinoma patients and 35 healthy volunteers were detected by enzyme linked immunosorbent assay (ELISA). The expression of Cat X in serum and the clinicopathological features of esophageal squamous cell carcinoma The relationship between. Results The serum Cathepsin X level in patients with esophageal squamous cell carcinoma was significantly higher than that in healthy subjects (P <0.01). The level of Cathepsin X in patients with esophageal squamous cell carcinoma was significantly correlated with the stage and lymph node metastasis of esophageal squamous cell carcinoma (P <0.05). Conclusion Serum Cat X may be a new tumor marker, which is helpful for the early diagnosis of esophageal squamous cell carcinoma, prediction of prognosis and the judgment of invasion and metastasis.