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目的:观察应用布地奈德氧驱雾化吸入配合鼻塞持续气道正压通气(NCPAP)治疗新生儿呼吸窘迫综合征(RDS)的临床疗效。方法:选取2011年11月~2013年11月在该院住院且符合诊断标准的RDS早产儿98例,随机分成治疗组和对照组,每组49例。对照组给予综合治疗配合NCPAP,治疗组在此基础上给予布地奈德氧驱雾化吸入治疗。结果:治疗组5例改用机械通气,占10.20%;对照组13例改用机械通气,占26.53%,两组比较差异有统计学意义(P<0.05);治疗组6例需重复使用肺表面活性物质(PS),占12.24%;对照组14例,占28.57%,差异有统计学意义(P<0.05);治疗组吸气性三凹征较对照组明显改善,吸氧时间较对照组缩短,差异有统计学意义(P<0.05)。结论:布地奈德氧驱雾化吸入配合鼻塞持续气道正压通气治疗RDS能减少PS的使用,减少机械通气,改善呼吸困难,缩短吸氧时间,有利于早产儿尽早停氧,防止出现肺部损伤,值得新生儿临床推广应用。
Objective: To observe the clinical efficacy of inhaled budesonide oxygen inhalation combined with nasal continuous positive airway pressure (NCPAP) in the treatment of neonatal respiratory distress syndrome (RDS). Methods: A total of 98 premature infants with RDS who were hospitalized and met the diagnostic criteria from November 2011 to November 2013 were randomly divided into treatment group (n = 49) and control group (n = 49). The control group was given comprehensive treatment with NCPAP, and the treatment group was given budesonide oxygen inhalation therapy on the basis of this. Results: In the treatment group, 5 cases were switched to mechanical ventilation, accounting for 10.20%. In the control group, 13 cases were switched to mechanical ventilation, accounting for 26.53%. There was significant difference between the two groups (P <0.05) (PS), accounting for 12.24%; control group, 14 cases, accounting for 28.57%, the difference was statistically significant (P <0.05); treatment group inhalation triple recess sign was significantly improved compared with the control group, oxygen inhalation time than the control Group shortened, the difference was statistically significant (P <0.05). Conclusions: Budesonide inhalation combined with nasal continuous positive airway pressure therapy can reduce the use of PS, reduce mechanical ventilation, improve dyspnea, shorten the time of oxygen inhalation, and prevent oxygen in the premature infants as soon as possible to prevent the occurrence of pulmonary Ministry of injury, it is worth promoting the clinical application of newborns.