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为了调查乙型肝炎病毒感染后宫内感染情况和胎儿的免疫反应,我们检查了17名HBsAg阳性的孕妇和她们生的17名婴儿的HBV血清学标志。结果17名母亲静脉血HBsAg滴度1:16—1:512,仅有一名新生儿的脐血HBsAg阳性,滴度是1:32,8名和1名母亲的HBeAg和抗-HBe分别是阳性。2名HBeAg阳性母亲所生新生儿脐血HBeAg阳性。2名新生儿抗-HBe阳性,其中有一名的母亲折-HBe亦是阳性。共有16名母亲和12名新生儿抗-HBc阳性,13名母亲和7名新生儿抗-HBc·IgM是阳性。在抗-HBc·IgM阴性的孕妇中,HBeAg可能是HBV宫内感染的重要因素。
To investigate the intrauterine infection of the hepatitis B virus and the immune response of the fetus, we examined HBV serology markers in 17 HBsAg-positive pregnant women and 17 infants born to them. Results In 17 mothers, HBsAg titer of venous blood was 1: 16-1: 512. Only one newborn had HBsAg positive in umbilical cord blood. The titer of HBsAg was 1: 32.8, and one mother was positive for HBeAg and anti-HBe respectively. Two newborns born to HBeAg-positive mothers had HBeAg-positive cord blood. Two newborns were anti-HBe positive, one of whom had a positive fold of -Be. A total of 16 mothers and 12 newborn anti-HBc positive, 13 mothers and 7 newborn anti-HBc IgM is positive. In anti-HBc-IgM-negative pregnant women, HBeAg may be an important factor in HBV intrauterine infection.