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目的 探讨血清心肌肌钙蛋白I(cTnI)评估新生儿窒息后的心肌损害的临床价值。方法 采用ELISA法对 2 0例窒息新生儿和 2 5例正常新生儿进行cTnI检测 ,同时检测肌酸磷酸激酶同功酶 (CK -MB)。结果 窒息组急性期血清cTnI、CK -MB水平明显高于对照组 (P <0 .0 5 ) ,且窒息时间越长 ,血清cTnI、CK -MB水平升高越明显 ,cTnI诊断新生儿窒息后心肌损伤的特异性均优于CK -MB。结论 血清cTnI和CK -MB的测定有助于早期预测心肌细胞损害 ,cTnI优于CK -MB
Objective To investigate the clinical value of serum cardiac troponin I (cTnI) in assessing myocardial damage after neonatal asphyxia. Methods Twenty cases of neonatal asphyxia and 25 normal neonates were tested for cTnI by ELISA and creatine phosphokinase isoenzyme (CK-MB). Results Serum levels of cTnI and CK-MB in the asphyxia group were significantly higher than those in the control group (P <0.05). The longer the asphyxia time was, the more obvious the serum cTnI and CK-MB levels were increased. After cTnI was used to diagnose neonatal asphyxia The specificity of myocardial injury are better than CK-MB. Conclusion The determination of serum cTnI and CK-MB is helpful for the early prediction of cardiomyocyte damage, cTnI is superior to CK-MB