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对输血后肝炎的前瞻性研究提示非甲非乙型肝炎往往进展为慢性肝病,但对这种慢性肝病的长期后果及其临床意义尚不明。本文报道21例输血后非甲非乙型肝炎发病后随访5年的结果。所有病例均作过外科心脏直视术,术前都无肝功能异常的生化依据。手术期间输过8～23单位全血或血浆,嗣后2～13周转氨酶水平增高(超过正常值上限的3倍),急性期HB_sAg测定(放射免疫法)均阴性,并排除中毒性肝病及充血性心力衰竭。21例分为二组:(1)A组:15例抗-HAV均阴性;抗-HB_s和抗-HB_c阴性13例,另2例入院时抗-HB_s和抗-HB_c已阳性。所有病例在急性期作肝活检,并以
Prospective studies of posttransfusion hepatitis suggest that non-A, non-B hepatitis often progresses to chronic liver disease, but the long-term consequences and clinical implications of this chronic liver disease are unknown. This article reports the results of 21 patients who were followed up for 5 years after the onset of non-A, non-B hepatitis after transfusion. All cases were treated with surgical heart surgery, no liver biochemical evidence of preoperative biochemical basis. During the operation, 8-23 units of whole blood or plasma were lost during the operation, and the levels of aminotransferases increased from 2 to 13 weeks later (more than 3 times the upper limit of normal). In the acute phase, the HBsAg assay (radioimmunoassay) was negative and the toxic liver disease and hyperemia Heart failure. 21 cases were divided into two groups: (1) Group A: 15 cases were negative for anti-HAV; 13 cases were negative for anti-HBs and anti-HBc; the other 2 cases were positive for anti-HBs and anti-HBc on admission. All cases in the acute phase of liver biopsy, and to