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目的探讨人Toll样受体4(TLR4)在非小细胞肺癌(NSCLC)患者组织中的表达及其与临床病理特征之间关系。方法对49例非小细胞肺癌患者(观察组)和20例癌旁肺组织(对照组)进行TLR4表达免疫组化方法检测及分析。结果观察组与对照组患者的TLR4阳性表达率差异有统计学意义(P<0.05);非小细胞肺癌患者中TLR4的表达与患者肿瘤的分化程度相关(P<0.05),而与患者的年龄、性别、TNM分期、是否吸烟以及淋巴结转移等临床病理之间差异无统计学意义(P>0.05)。结论 NSCLC患者TLR4表达率明显增高,其表达情况与NSCLC症状的发生发展有关,值得进一步研究。
Objective To investigate the expression of human Toll-like receptor 4 (TLR4) in non-small cell lung cancer (NSCLC) and its relationship with clinicopathological features. Methods Totally 49 cases of non-small cell lung cancer (observation group) and 20 cases of paracancer lung tissue (control group) were detected by immunohistochemistry and TLR4 expression. Results The expression of TLR4 in observation group and control group was significantly different (P <0.05). The expression of TLR4 in non-small cell lung cancer was correlated with the degree of tumor differentiation (P <0.05), but not with the age of patients , Gender, TNM stage, whether smoking and lymph node metastasis and other clinical pathological differences were not statistically significant (P> 0.05). Conclusion The expression of TLR4 in NSCLC patients is significantly higher than that in NSCLC patients. The expression of TLR4 is associated with the occurrence and development of NSCLC symptoms and deserves further study.