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脑卒中导致的脑神经元凋亡过程中,存在着大量正性和负性的可调控相关因子,这些可调控因子可作为治疗脑卒中的潜在靶点。研究表明,脑卒中神经元细胞凋亡主要是由Caspase的级联反应所调控,细胞凋亡的主要途径之一是线粒体凋亡通路,Bcl-2家族蛋白主要调节Caspase的激活。线粒体释放的与凋亡相关的因子也对Caspase的激活有调节作用,而这些与凋亡相关的因子又受Bcl-2蛋白所调节。对脑卒中神经元凋亡过程中线粒体途径调控相关因子的研究是寻找和开发治疗脑卒中药物的重要理论基础。
During the process of stroke-induced neuronal apoptosis, there are a large number of positive and negative regulatory factors that can be used as potential targets for the treatment of stroke. Studies have shown that apoptosis of neurons in stroke is mainly regulated by the Caspase cascade. One of the main pathways of apoptosis is the mitochondrial apoptosis pathway. The Bcl-2 family protein mainly regulates the activation of Caspase. Mitochondrial release of apoptosis-related factors also regulate caspase activation, and these apoptosis-related factors are regulated by Bcl-2 protein. The study of mitochondrial pathway-related factors in the process of stroke neuronal apoptosis is an important theoretical basis for the search and development of drugs for the treatment of stroke.