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以蒙脱土(MMT)为原料,进行有机改性制备了有机MMT并与壳聚糖(CS)进行插层复合反应,制得CS/MMMT复合材料,并进行了FT-IR、XRD、TG、SEM和EDS表征。FT-IR和XRD结果表明CS分子插层进入MMT的层间,有较好的物理交联的作用,EDS表明复合材料中C元素的含量增多,也证明CS分子插层进入层间,TG结果表明在失重率为60%时,CS∶MMT的配合比为1∶9时的CS/MMT复合材料,热分解温度为438℃,热稳定性提高。以盐酸金霉素为载药模型,考察了CS/MMT复合材料对盐酸金霉素药物的缓释效果,结果表明随着MMT含量的增加,MMT片层阻碍了CS分子的运动,提高了CS分子的耐溶蚀性,缓释率降低。当CS∶MMT的配合比为1∶9时,缓释时间3h,CS/MMT复合材料负载的盐酸金霉素的缓释率为25%,缓释时间从3h到7h缓释率基本保持平衡。
MMT as raw material, organic modified MMT was prepared and chitosan (CS) intercalation compound reaction CS / MMMT composite material, and the FT-IR, XRD, TG , SEM and EDS characterization. The results of FT-IR and XRD show that the CS molecules intercalate into the interlayer of MMT, which has a good physical crosslinking effect. EDS shows that the content of C element in the composite material increases, which also proves that the intercalation of CS molecules into the interlayer, TG results The results show that the CS / MMT composites with CS: MMT ratio of 1: 9 at the weight loss of 60% have a thermal decomposition temperature of 438 ℃ and higher thermal stability. The chlortetracycline hydrochloride drug-loading model was used to investigate the sustained-release effect of CS / MMT composite on chlortetracycline hydrochloride. The results showed that with the increase of MMT content, the MMT sheet obstructed the movement of CS molecules and increased the CS Molecule corrosion resistance, slow release rate. When the ratio of CS: MMT was 1: 9, the release rate of chlortetracycline hydrochloride loaded with CS / MMT composite was 25% at 3h, and the sustained release rate of 3h-7h slow release rate was basically balanced .