论文部分内容阅读
本文调查了5名SLE患者及其家族成员共50人的病史。对患者及其家族中未发病的存活成员共29人做了染色体分析。结果表明:(1)有4个家族,患者及其双亲中一方或双方的染色体畸变率显著高于健康人;患者畸变染色体在A～G各组内的分布百分比以及畸变类型也与父亲或母亲相似。(2)患者的8名同胞中有6名染色体畸变率显著高于健康人;有一部分同胞,其畸变染色体在A～G各组内的分布百分比及畸变类型也与患者的相似。上述结果提示:患者染色体脆性高,损伤后修复能力低的这种遗传素质来自父亲或母亲;同胞之间也存在着一定的亲缘关系。
This article investigates the history of five SLE patients and their family members for a total of 50 people. Chromosome analysis was performed on 29 of the unaccredited surviving members of the patients and their families. The results showed that: (1) The chromosome aberration rate in one of four families, patients and one or both parents was significantly higher than that in healthy subjects; the distribution percentage of aberrant chromosomes in groups A to G, similar. (2) Six of the eight siblings had significantly higher chromosome aberration rates than healthy subjects. Some of the siblings also had similar distributions and types of aberrations in the A ~ G groups. These results suggest that: patients with high chromosomal fragility, low repair capacity after injury, this genetic quality comes from the father or mother; siblings also have some kinship.