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目的探讨甲状腺癌与人端粒酶逆转录酶的关系及其调节机制。方法参阅国内外相关文献就人端粒酶逆转录酶与甲状腺癌组织的关系及其调控机制作一综述。结果人端粒酶逆转录酶在甲状腺癌发生发展中起重要作用并受多种因素调节。结论人端粒酶逆转录酶对甲状腺癌的诊断、预后估计及针对端粒酶逆转录酶的抑制剂在甲状腺癌的基因治疗中具有重要的临床意义。
Objective To investigate the relationship between thyroid cancer and human telomerase reverse transcriptase and its regulatory mechanism. Methods A review was made on the relationship between human telomerase reverse transcriptase and thyroid cancer tissue and the production of regulatory machinery. Results Human telomerase reverse transcriptase plays an important role in the development of thyroid cancer and is regulated by many factors. Conclusion The diagnosis and prognosis of human telomerase reverse transcriptase for thyroid cancer and the inhibitors against telomerase reverse transcriptase have important clinical significance in the gene therapy of thyroid cancer.