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使用各种苄硫基醛和酮作为羰基化结构单元通过Ugi四组分反应合成了完全保护的天然的和非天然的N-乙酰半胱氨酸,二肽Cys-Gly,谷胱甘肽和相似的谷胱甘肽衍生物。研究了方法的限制范围。讨
The fully protected natural and non-native N-acetylcysteine, the dipeptides Cys-Gly, glutathione and glutathione, were synthesized by Ugi four-component reaction using various benzylthio aldehydes and ketones as carbonylation building blocks Similar glutathione derivatives. The limits of the method are studied. discuss