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麻风化学治疗药物目前仅有4种,即氨苯砜、氯苯吩嗪、硫酰胺类药物(乙硫异烟胺和丙硫异烟胺)和利福平.然而、由于氨苯砜和利福平耐药菌株的出现,氯苯吩嗪的皮肤变色,以及硫酰胺类药物的肝脏毒性等问题,所以,寻找新的抗麻风药物则是迫切需要的.甲氟哌酸(Pefloxacin,PF)和环丙氟哌酸(Ciprofloxacin,CP)是具有抗多种分支杆菌活性的氟喹啉酮类似物.为了评价这两种药物抗麻风杆菌的活性,在小鼠中进行了药物
Currently there are only 4 leprosy chemotherapeutic agents, namely, dapsone, clofazin, thioamides (ethionamide and prothionamide) and rifampin, however, since dapsone and levofloxacin The emergence of drug-resistant strains of Fuping, the skin discoloration of chlorophenazine and the hepatotoxicity of sulfonamides.However, the search for new anti-leprosy drugs is urgently needed.Fufloxacin (PF) And Ciprofloxacin (CP) are fluoroquinolone analogs with activity against a wide range of mycobacteria To evaluate the activity of both drugs against M. leprae, drugs were administered in mice