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目的:探讨盐酸羟考酮控释片(商品名:奥施康定,oxycontin)直肠给药联合硬膜外自控镇痛(PCEA)用于胃癌术后镇痛的疗效以及安全性。方法:将100例胃癌患者随机分为4组,A组采用PCEA镇痛,B组采用PCEA+盐酸羟考酮控释片塞肛镇痛,C组采用盐酸羟考酮控释片塞肛镇痛,D组采用半量PCEA及盐酸羟考酮控释片塞肛镇痛。观察记录各组患者的术后镇痛效果、肠鸣音恢复情况、肛门排气时间,以及恶心、呕吐和便秘等不良反应。结果:4组镇痛效果满意率的差异有统计学意义,P=0.011;B、D两组镇痛效果满意度高于A、C两组;4组肛门排气时间之间的差异有统计学意义,P<0.05;C、D两组的肛门排气时间短于A、B两组,P<0.05。结论:半量的盐酸羟考酮控释片联合PCEA用于胃癌术后镇痛效果可靠,且对肠功能恢复无明显影响。
Objective: To investigate the efficacy and safety of oxycodone hydrochloride controlled-release tablets (product name: oxycontin) combined with rectal administration of epidural analgesia (PCEA) for postoperative analgesia of gastric cancer. Methods: One hundred patients with gastric cancer were randomly divided into 4 groups: group A received PCEA analgesia, group B received PCEA + oxycodone hydrochloride analgesic patch analgesia, group C received oxycodone hydrochloride controlled release patch anal anal pain In group D, PCEA and oxycodone hydrochloride analgesic analgesic analgesia were used in group D. Postoperative analgesia, bowel sounds recovery, anal exhaust time, nausea, vomiting and constipation were recorded and recorded in each group. Results: The satisfaction rate of analgesic effect in 4 groups was statistically significant (P = 0.011). The satisfaction degree of analgesic effect in groups B and D were higher than those in groups A and C Significance, P <0.05; C, D two groups of anal exhaust time is shorter than A, B two groups, P <0.05. Conclusion: A half of oxycodone hydrochloride controlled release tablets combined with PCEA for postoperative analgesia of gastric cancer is reliable and has no obvious effect on the recovery of intestinal function.