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目的:观察a-硫辛酸(ALA)联合甲钴胺对2型糖尿病患者周围神经病变的疗效.方法:筛查2型糖尿病周围神经病变患者80例,随机分为两组.治疗组40例予ALA联合甲钴胺治疗2周,对照组40例予甲钴胺治疗2周.分别于治疗前后进行症状总评分(TSS)评分及测定血清C反应蛋白(CRP).结果:治疗组的TSS评分较对照组改善明显,治疗组的CRP水平较对照组下降明显(P均<0.05).结论:ALA联合甲钴胺治疗糖尿病周围神经病变效果明显.“,”Objective To evaluate the effect of the therapy of a-lipoic acid combined with mecobalamin on diabetic peripheral neuropathy(DPN). Methods 80 type 2 diabetic patients complicated with DPN were randomly divided into 2 groups: treatment group(n=40),receiving ALA combined with mecobalamin therapy for 2 weeks;and control group(n=40),receiving mecobalamin therapy for 2 weeks.Total symptom score(TSS) were used to evaluate ,CRP was measured before and after the therapy. Results Compaired with the control group ,the TSS of the treatment group were improved better, the level of CRP was reduced significantly(both P<0.05).Conclusions ALA combined with mecobalamin effectively improve the symptom of DPN patients.