目的:探讨NO在病毒性肝炎中的作用及机制。方法:用分光光度比色分析法检测83例病毒性肝炎患者血清NO和内毒素水平。结果:各病毒性肝炎组NO和内毒素水平均高于正常对照组(P<0.01),重型肝炎组NO水平低于急性和慢性组(P<0.01),而内毒素水平高于急性和慢性组(P<0.01)。结论:病毒性肝炎患者NO水平明显升高,且可能对肝脏有保护作用, Objective: To explore the role of NO in viral hepatitis and its mechanism. Methods: Serum NO and endotoxin levels were measured in 83 patients with viral hepatitis by spectrophotometry. Results: The levels of NO and endotoxin in each viral hepatitis group were significantly higher than those in normal control group (P <0.01). The levels of NO in severe hepatitis group were lower than those in acute and chronic groups (P <0.01), while the levels of endotoxin were higher than acute and chronic Group (P <0.01). Conclusion: The level of NO in patients with viral hepatitis is significantly increased, and may have a protective effect on the liver,