众所周知,动脉硬化形成与很多原因有关,其中以高脂血症和血栓形成为代表,但临床遇到与“动脉硬化危险因子”关系不大,而有冠状动脉病变者并不少见。在血液高凝状态下容易引起血栓形成,这是动脉硬化的重要危险因索,在血液凝固因子中第Ⅷ因子低下或缺乏的血友病患者很少形成血栓,也很少有动脉硬化症。1975年Stewart氏报告关于血友病患者因心肌梗塞死亡尸检时发现冠状动脉、主动脉有明显的粥样硬化性病变,作者认为本病难以引起血栓形成,临床血液学的研究并不认为与血栓形成有关。Duguid氏对冠状动脉硬化引起血管狭窄的血栓学说也表示怀疑,提出脂质代谢紊乱是冠状动脉硬化的病因。最近Small氏观察到因心肌梗塞死亡的血友病患者在冠状动脉上有明显血栓形成。便1,57岁。第Ⅷ因子1u/dl以下,大量出血时补充第Ⅷ因子年内2000u,这种病人一般每年应补充40,000u,该患者补充第Ⅷ因子是明显不足的。入院后因持续呕血在输血同时补充第Ⅷ因子,一般情况好 As we all know, the formation of atherosclerosis and many reasons, including hyperlipidemia and thrombosis as the representative, but the clinical encounter with the “risk factors for arteriosclerosis” little, but coronary artery lesions are not uncommon. In the hypercoagulable state prone to cause thrombosis, which is an important risk factor for atherosclerosis, blood coagulation factor factor VIII is low or lack of hemophilia seldom thrombosis, and very few arteriosclerosis. 1975 Stewart’s report on the death of hemophiliacs due to myocardial infarction autopsy found coronary artery, the aorta obvious atherosclerotic lesions, the authors believe that the disease is difficult to cause thrombosis, clinical hematology and does not think the thrombus Formed about. Duguid’s also questioned the thrombus theory of vascular stenosis caused by coronary arteriosclerosis, suggesting that lipid metabolism disorders are the cause of coronary atherosclerosis. Small recently observed hemophiliac death in patients with myocardial infarction in the coronary artery obvious thrombosis. It is 1,57 years old. Ⅷ factor 1u / dl the following, a large number of hemorrhage to supplement factor VIII during the year 2000u, such patients should generally be added 40,000u per year, the patient supplements factor Ⅷ is obviously inadequate. Due to continuous vomiting after admission blood transfusions in the same time add factor VIII, the general situation is good