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鼠疫耶尔森氏菌(Yersinia pestis,以下简称“鼠疫菌”)是烈性传染病鼠疫的病原菌,以鼠蚤作为传播媒介。鼠疫菌在其传播媒介鼠蚤的前胃中形成生物被膜从而促进其在宿主间传播。鼠疫菌生物被膜的形成受第二信使分子环二鸟苷酸(c-di-GMP)的正向调控。鼠疫菌中c-di-GMP由二鸟苷酸环化酶(DGC)HmsT和HmsD合成,由磷酸二酯酶(PDE)HmsP降解。文中主要介绍影响鼠疫菌环二鸟苷酸代谢及生物被膜形成的调控因子,并对其作用机制进行讨论和总结。
Yersinia pestis (hereinafter referred to as “Yersinia pestis”) is the pathogen of the potent infectious disease plague and uses the flea as a transmission medium. Yersinia pestis forms a biofilm in the anterior stomach of its vector rat flea to promote its spread between hosts. The formation of Y. pestis biofilm is positively regulated by the second messenger molecule, cyclic di-guanosine (c-di-GMP). C-di-GMP from Yersinia pestis is synthesized by two guanylate cyclase (DGC) HmsT and HmsD and degraded by phosphodiesterase (PDE) HmsP. In this paper, we mainly introduce the regulatory factors that affect the metabolism of two guanylate acids and the formation of biofilm in Yersinia pestis, and discuss the mechanism of action.