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目的探讨卵巢癌患者化疗期间在不同时间点症状群的变化规律及其与生活质量的关系。方法选取2012年2月至2015年2月间完成5次化疗的112卵巢癌患者作为研究对象,在4个不同时间点对患者进行问卷调查。应用基于记忆症状评估量表(MSAS)和卵巢癌患者生命质量测定量表(FACT-O)对患者症状严重程度以及生活质量进行评价和纵向对比。结果分析各症状的主成分,共提取出躯体化症状群、情感性症状群、胃肠道症状群和不良反应症状群。在T1时期出现2个症状群,T2~T3时期均出现4个症状群。方差结果显示,卵巢癌患者在化疗期间不同时间点的生活质量总分差异有统计学意义(P<0.05)。卵巢癌患者化疗期间不同时间点的生活质量各维度评分中,功能状况维度评分最低,其次是生理状况。结论卵巢癌患者在化疗过程中存在多个严重影响患者生活质量的症状群,护师应根据患者在化疗期间每个阶段症状群的严重程度,有侧重地进行干预,准确及时地对症状进行评估,并进行有效管理,以提高患者的生活质量。
Objective To investigate the changes of symptoms in ovarian cancer patients at different time points during chemotherapy and its relationship with the quality of life. Methods A total of 112 ovarian cancer patients who completed 5 cycles of chemotherapy between February 2012 and February 2015 were selected as the research subjects and the patients were surveyed at 4 different time points. The symptom severity and quality of life of the patients were assessed and compared longitudinally using the Memory Symptom Assessment Scale (MSAS) and the Ovarian Cancer Quality of Life Scale (FACT-O). Results The main components of each symptom were analyzed. Somatic symptom group, affective symptom group, gastrointestinal symptom group and adverse reaction symptom group were extracted. There were 2 symptoms in T1 and 4 symptoms in T2 ~ T3. Variance results showed that the total score of quality of life in ovarian cancer patients at different time points during chemotherapy was significantly different (P <0.05). Ovarian cancer patients at different time points during the quality of life scores in all dimensions, functional status score the lowest, followed by the physiological status. Conclusions There are several symptoms in ovarian cancer patients during chemotherapy, which may seriously affect the quality of life of patients. Nurses should focus on the severity of the symptom group at each stage of chemotherapy and intervene accurately and timely to evaluate the symptoms , And effective management to improve the quality of life of patients.