Objective:To investigate the protective effects of brown algaPadina boergesenii(P. boergeseii) against carbon tetrachloride(CCl4) induced oxidative damage and liver fibrosis in rats.Methods:To assess the hepatic damage liver weight, the activities of TBARS level, glutathione,SOD, CAT andGPx in circulation and liver.Results:The group of rats induced withCCl4 alone (2 mL/kg body weight), showed noticeable increase in the liver weight and TBARS level. Followed by, the level of antioxidant enzymes glutathione peroxidase, Superoxide dismutase and catalase was also significantly(P<0.01) diminished. Where as, the rats pretreated withP. boergesenii (150 mg/kg body weight) modulated theCCl4induced liver fibrosis. The level of antioxidant enzymes and lipid peroxidation products was found to be significantly(P<0.01) attenuated to near normal level, when compared with rats induced withCCl4alone. In order to assess the role of carotenoids in the relevant activity, total carotenoid content of the extract was analysed and found to be0.59 mg/g fresh weight (FW). Further, the histopathogical studies provide a supportive evidence for this study to show the protective nature ofP. boergesenii.Conclusions: The protective role of brown algaP. boergesenii extract has confirmed its potential activity through its antioxidant sparing actions against CCl4 induced free radical damage. However, the possible mechanism of hepatoprotection is rather speculative at this stage and investigations are underway to isolate and characterize the bioactive compounds fromP. boergesenii.