胞内寄生菌包括产单核细胞李氏菌、结核杆菌、流产布氏菌等能寄生在巨噬细胞及其他吞噬细胞内。在感染细菌后的恢复上,分泌IFN-γ的CD4~+T细胞起了重要作用,而抗体的作用较为次要。有实验证明,只有免疫减毒活疫苗的胞内菌能高效诱导典型的IFN-γ分泌性Th1细胞,形成满意的获得性细胞抵抗力(ACR)、作者为探讨其机制,将死或活的布氏杆菌、李氏菌分别与巨噬细胞共同培养,观察巨噬细胞产生TNF-α,IL-1和IL-6的差异。 Intracellular parasites include Listeria monocytogenes, Mycobacterium tuberculosis, abortion, such as brucellosis can be parasitic in macrophages and other phagocytes. CD4 ~ + T cells secreting IFN-γ play an important role in the recovery after infection with bacteria, and the role of the antibody is less important. It has been experimentally shown that only the intracellular bacteria of the live-attenuated vaccine can efficiently induce the typical IFN-γ-secreting Th1 cells to form a satisfactory acquired cell resistance (ACR). The authors investigated the mechanism of death or viability Brucella and Listeria were co-cultured with macrophages respectively to observe the difference of TNF-α, IL-1 and IL-6 produced by macrophages.