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目的分析血清IL-6、MCP-1、Cys-C、apelin水平与妊娠并糖尿病的相关性。方法选择2012年4月-2015年2月入我院确诊妊娠并定期做产检的孕妇206例,在孕24~28周对患者进行口服糖耐量试验,根据其试验结果将孕妇分为正常妊娠组(100例),妊娠并糖尿病组(106例),检测并对比2组血清IL-6、MCP-1、Cys-C、apelin水平。结果妊娠并糖尿病组血清IL-6、MCP-1、Cys-C、apelin水平均高于正常妊娠组,差异均有统计学意义(P<0.05)。结论血清IL-6、MCP-1、Cys-C、apelin水平与妊娠并糖尿病具有一定的相关性,在临床上能作为妊娠并糖尿病辅助诊断的血清学指标。
Objective To analyze the correlation between serum IL-6, MCP-1, Cys-C, apelin and gestational diabetes mellitus. Methods A total of 206 pregnant women with confirmed pregnancy and regular check-up were selected from April 2012 to February 2015 in our hospital. Oral glucose tolerance test was conducted in 24 to 28 weeks pregnant women. According to the test results, pregnant women were divided into normal pregnancy group (100 cases) and gestational diabetes mellitus (106 cases). The serum levels of IL-6, MCP-1, Cys-C and apelin in the two groups were detected and compared. Results The levels of serum IL-6, MCP-1, Cys-C and apelin in gestational diabetes mellitus group were significantly higher than those in normal pregnancy group (P <0.05). Conclusion Serum levels of IL-6, MCP-1, Cys-C, apelin have a certain correlation with gestational diabetes mellitus, and can be used as a serological marker in the diagnosis of gestational diabetes mellitus.