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[目的]研究体质指数对膀胱癌根治性全切患者治疗及预后的影响。[方法]回顾性采集427例因膀胱癌行根治性全切患者的临床病理信息、治疗过程和随访结局,根据BMI将患者分成3组,分别是正常组(BMI<23kg/m~2)、超重组(BMI 23kg/m~2~24.9kg/m~2)和肥胖组(BMI≥25kg/m~2),采用单因素方差分析和非参数检验比较患者特征,通过Kaplan-Meier生存分析及单因素、多因素Cox回归分析预后差异。[结果]正常组、超重组和肥胖组的患者例数分别是148例、122例及157例。在基础临床特征方面,BMI高者合并高血压的比例较高(P=0.002);治疗过程方面,BMI高者手术时间长(P=0.001)、术中出血多(P=0.007);各组病理结局(肿瘤分期、分级、淋巴结状态)无明显差异。Kaplan-Meier分析显示3组的总体生存率和肿瘤特异性生存率无统计学差异。[结论]BMI高的膀胱全切患者合并高血压比例较高,手术时间较长,术中出血较多,但BMI对患者预后无明显影响。
[Objective] To study the effect of body mass index on the treatment and prognosis of patients with radical resection of bladder cancer. [Methods] The clinicopathological information, course of treatment and follow-up of 427 patients undergoing radical total curative resection of bladder cancer were retrospectively collected. The patients were divided into 3 groups according to BMI: normal group (BMI <23kg / (BMI 23kg / m ~ 2 ~ 24.9kg / m ~ 2) and obesity group (BMI≥25kg / m ~ 2) by single factor analysis of variance and nonparametric test. The Kaplan-Meier survival analysis Univariate and multivariate Cox regression analysis of prognostic differences. [Results] The number of patients in normal group, overweight group and obesity group were 148 cases, 122 cases and 157 cases respectively. In terms of basic clinical features, the high proportion of patients with high BMI had a higher proportion of patients with hypertension (P = 0.002). In terms of the course of treatment, the patients with high BMI had a longer operation time (P = 0.001) and more intraoperative bleeding (P = 0.007) Pathological outcome (tumor staging, grading, lymph node status) no significant difference. Kaplan-Meier analysis showed no significant difference in overall survival and tumor-specific survival between the three groups. [Conclusion] The patients with high BMI with total cystectomy have a higher proportion of patients with hypertension, longer operation time and more intraoperative bleeding. However, BMI has no significant effect on the prognosis of patients.