论文部分内容阅读
以新异味觉刺激糖精水的摄入为条件刺激，以腹腔注射环磷酰胺（ＣＹ，免疫抑制剂）或氯化锂（ＬｉＣｌ）为非条件刺激，分别使大鼠建立味觉厌恶性条件反射。在条件刺激日，糖精水在学习组大鼠下列脑区中诱发出密集的Ｆｏｓ表达：下丘脑、杏仁核、边缘皮质等，而非学习组在这些区域中却没有或只有少量表达。另外，在丘脑前背侧核、扣带回、下丘脑外侧核、穹隆下器、压部后颗粒皮质、视上核，ＣＹ组的Ｆｏｓ表达明显多于ＬｉＣ１组；而在伏核、杏仁基底外侧核、腹外侧隔核，ＬｉＣｌ组的Ｆｏｓ表达明显多于ＣＹ组，这种差异可能是两种药物的不同药理性质所致。
To stimulate the intake of saccharin water stimulated by the new odor sensation, intraperitoneal injection of cyclophosphamide (CY, immunosuppressant) or lithium chloride (LiCl) as unconditioned stimuli, respectively, to establish the taste-aversive conditioned reflex in rats. On conditioned stimulation days, saccharin water induced intensive Fos expression in the brain regions of hypothalamus, amygdala, and marginal cortex in the study group rats, whereas the non-study group had no or only a small amount of expression in these regions. In addition, the Fos expression in CY group was significantly higher than that in LiC1 group in dorsal nucleus of anterior thalamus, cingulate gyrus, lateral hypothalamic nucleus, subfornal crest, posterior granular cortex and supraoptic nucleus. In the nucleus accumbens, Fos expression in LiCl group was significantly higher than that in CY group in the lateral nucleus and ventral lateral septum. This difference may be due to the different pharmacological properties of the two drugs.