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血凝素样氧化低密度脂蛋白受体(LOX-1),是氧化低密度脂蛋白(ox-LDL)特异性受体,其与配体结合后具有损伤内皮细胞功能、促进局部炎症反应、增加局部氧化应激等作用。近年来的大量研究显示LOX-1与经皮冠状动脉成形术(PTCA)术后再狭窄有关,现就近年来LOX-1及其在PTCA术后再狭窄中的作用研究进展作一综述,以期进一步了解PTCA术后再狭窄发病机理,为临床治疗PTCA术后再狭窄提供帮助。
The hemagglutinin-like oxidized low density lipoprotein receptor (LOX-1) is an ox-LDL-specific receptor that binds to ligands to impair the function of endothelial cells and promote local inflammatory responses. Increase the role of local oxidative stress. In recent years, a large number of studies have shown that LOX-1 and percutaneous transluminal coronary angioplasty (PTCA) postoperative restenosis, now on LOX-1 and its role in the restenosis after PTCA research progress is reviewed in order to further To understand the pathogenesis of postoperative restenosis after PTCA, for the treatment of postoperative PTCA restenosis help.