目的　观察培氟沙星治疗慢性阻塞性肺病合并急性肺部感染的疗效。方法　依照慢性阻塞性肺病的诊断标准 ,选择合并肺部感染的 64例患者 ,所有病例均予以痰细菌培养 ,全部病例均给予pefloxacin每天 0 8g ,分 2次口服 ,重症病例 0 8g静脉注射 ,疗程 7～ 2 1d ,平均 9 15d。结果　显效 3 8例 ,有效 12例 ,进步 8例 ,无效 6例 ,总有效率 84 5 %。结论　pefloxacin在治疗COPD合并急性肺部感染特别是院外获得性肺炎有较好疗效 Objective To observe the curative effect of pefloxacin on patients with chronic obstructive pulmonary disease complicated by acute pulmonary infection. Methods According to the diagnostic criteria of chronic obstructive pulmonary disease (COPD), 64 patients with pulmonary infection were selected and sputum bacterial culture was performed in all cases. All patients were given pefloxacin 0 8g daily, 2 times orally and 0 8g severe cases were treated by intravenous injection. 7 ~ 2 1d, an average of 915d. Results 38 cases markedly effective in 12 cases, 8 cases improved, 6 cases were ineffective, the total effective rate 84 5%. Conclusions Pefloxacin is effective in treating COPD with acute pulmonary infection, especially extra-nosocomial pneumonia