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作者曾于1959,1960年就证明了乙酰胆硷(Ac)可作用于离体蛙心,使心肌分泌出一种兴奋性物质——X因子。本文系观察用与Ac作用相似的拟胆硷物质及非胆硷物质(KCl)对心肌的效应,并且观察Ac对其他器官的效应来进一步阐明拟胆硷物质对心肌代谢的特异性影响,其结果如下: (1)用6倍KCl含量所配成的任格氏液灌注蛙心时,心肌仅出现抑制作用,不分泌X因子。 (2)拟胆硷物质即胆硷(1×10~(-4)γ/ml),碳化胆硷(1×10~(-5)γ/ml),乙酰-B-甲基胆硷(1×10~(-5)γ/ml)对心肌
The author had previously demonstrated in 1959 and 1960 that acetylcholine (Ac) could act on isolated frog hearts, causing the myocardium to secrete an excitable substance called X factor. In this paper, we observed the effects of quasi-cholesterol and non-cholinergic substances (KCl) similar to Ac on the myocardium, and observed the effect of Ac on other organs to further elucidate the specific effects of chymidine on myocardial metabolism. The results are as follows: (1) When infusion of Frog Hearts with Renqier solution of 6-fold KCl content, the myocardium only inhibited and did not secrete factor X. (2) The quasicholestamoid material is cholesterin (1×10 -4 γ/ml), carbonized cholesterin (1×10 -5 γ/ml), and acetyl-B-methylcholanthrene ( 1×10 -5 γ/ml) against myocardium