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目的探讨酒精性脂肪肝、酒精性肝炎、酒精性肝硬化患者TNF-a、MCV测定水平与肝损害进展的关系。方法酒精性脂肪肝患者30例,酒精性肝炎患者30例,酒精性肝硬化患者30例,正常对照组30例,测定血清TNF-a及全血MCV水平。结果 (1)酒精性肝炎、酒精性肝硬化患者血清TNF-a及全血MCV水平明显高于对照组,并随肝损害程度加重而进行性增加。(2)酒精性肝硬化患者的血清TNF-a及全血MCV水平明显高于酒精性肝炎患者的血清TNF-a及全血MCV水平。(3)酒精性肝炎患者的血清TNF-a及全血MCV水平明显高于酒精性脂肪肝患者的血清TNF-a及全血MCV水平。结论血清TNF-a及全血MCV水平随着酒精性肝损害由轻到重而升高,可作为反映酒精性肝损害程度的指标。
Objective To investigate the relationship between the levels of TNF-α and MCV in patients with alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis and the progress of liver damage. Methods Thirty patients with alcoholic fatty liver disease, 30 alcoholic hepatitis patients, 30 alcoholic cirrhosis patients and 30 normal control subjects were enrolled in this study. Serum TNF-a and whole blood MCV levels were measured. Results (1) Serum levels of TNF-a and whole blood MCV in patients with alcoholic hepatitis and alcoholic cirrhosis were significantly higher than those in the control group, and increased progressively with the severity of liver damage. (2) Serum TNF-a and whole blood MCV levels in patients with alcoholic cirrhosis were significantly higher than those in alcoholic hepatitis patients with serum TNF-a and whole blood MCV levels. (3) Serum TNF-a and whole blood MCV levels in patients with alcoholic hepatitis were significantly higher than those in patients with alcoholic fatty liver disease. Conclusions Serum levels of TNF-a and whole blood MCV are increased from mild to severe with alcoholic liver damage, which can be used as an index to reflect the degree of alcoholic liver damage.