论文部分内容阅读
目的:分析青年胃癌(≤45岁)的发病特点、病理类型和临床特征,为青年胃癌的预防和治疗提供理论依据。方法:采用胃癌数据库对22年间2158例胃癌资料数据进行筛选和研究,并对青年胃癌的发病特征、病理学情况和临床特征进行统计学分析。结果:青年胃癌以高度恶性弥漫型为主,好发部位为胃窦部和胃体胃角部。男女性比例接近,女性发病年龄低于男性,受遗传因素影响明显,男性更易累及。青年胃癌缺乏特异症状和体征,首次就诊至确诊时间平均为8.7个月,误漏诊率高达65.4%。经胃镜和X线钡餐诊断为胃癌的占66.5%,诊断时进展期占96.7%,仅31.9%可行根治性手术治疗,随访的193例患者2年生存率仅17.1%。结论:青年胃癌以高度恶性弥漫型为主,与遗传关系密切。青年胃癌误漏诊率高,确诊时多为进展期,预后差,临床上应提高警惕,特别是对于具有家族背景的高危人群、出现警惕症状者和病程较长的青年患者,应行X线钡餐和胃镜检查以排除胃癌。
Objective: To analyze the incidence, pathological type and clinical features of young gastric cancer (≤45 years old), and provide a theoretical basis for the prevention and treatment of young gastric cancer. Methods: A total of 2158 cases of gastric cancer data were screened and studied using gastric cancer database in 22 years. The incidence, pathology and clinical features of young gastric cancer were analyzed statistically. Results: The young patients with gastric cancer were mainly malignant and diffuse, and the predilection sites were gastric antrum and gastric stomach. The proportions of male and female are close, the incidence of female is lower than that of male, obviously influenced by genetic factors, and men are more likely to be involved. The lack of specific symptoms and signs of young patients with gastric cancer, the first diagnosis to an average of 8.7 months, the missed diagnosis rate as high as 65.4%. Gastroscopy and X-ray barium meal diagnosis of gastric cancer accounted for 66.5%, diagnosis of 96.7% of the progress, only 31.9% of radical surgery, radical follow-up of 193 patients 2 years survival rate was only 17.1%. Conclusion: The young patients with gastric cancer are mainly malignant and diffuse, and have close genetic relationship. Misdiagnosis of high risk of gastric cancer in young, mostly diagnosed as advanced, poor prognosis, clinical should be vigilant, especially for high-risk groups with family backgrounds, vigilance symptoms and longer duration of young patients should be performed barium meal And gastroscopy to rule out gastric cancer.