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HLA-G是一种非经典HLA-Ib类家族分子,最早被发现表达在母胎界面绒毛外滋养层细胞表面,其在与母体接触中向细胞内传递抑制性信号,抑制母体对胚胎异体抗原的免疫杀伤。目前多项研究发现,HLA-G在肿瘤的产生及免疫逃逸中均发挥了一定的作用,并且在实体器官移植的免疫耐受中也起了重要的作用[1-2],相对于实体肿瘤及实体器官移植,HLA-G在血液系统恶性疾病及造血干细胞移植中的作用,目前也有相关研究,现对其作一简要综述。
HLA-G, a non-classical HLA-Ib family of molecules, was first found to be expressed on the surface of trophoblastic cells outside the villi at the maternal-fetal interface. It transmits inhibitory signals to cells in contact with the maternal body and inhibits maternal responses to embryonic alloantigens Immune killing. At present, a number of studies have found that HLA-G plays a certain role in tumor production and immune escape, and also plays an important role in the immune tolerance of solid organ transplantation [1-2]. Compared with solid tumors And solid organ transplantation, the role of HLA-G in hematological malignancies and hematopoietic stem cell transplantation, there are also related studies, now a brief review of its.