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目的:分析研究丙戊酸钠联合托吡酯在小癫痫治疗当中的临床效果,为小儿癫痫的治疗提供参考与借鉴。方法:从2011年3月到2012年3月某医院所诊断的小儿癫痫患者当中随机抽取168例患儿,随机分为3个小组,即丙戊酸钠组、托吡酯组,丙戊酸钠联合托吡酯组。给予丙戊酸钠组的患儿丙戊酸钠,其初始的剂量为10mg/(kg·d)左右,每天3次,然后逐渐增加用药剂量,但不超过40mg/(kg·d),次数不变;给予托吡酯组的患儿托吡酯,初始剂量0.75mg/(kg·d),然后增加用药剂量,维持在6mg/(kg·d)左右,每天服用2次;丙戊酸钠联合托吡酯组的用药剂量和方法和上述相同。结果:丙戊酸钠、托吡酯组、和丙戊酸钠联合托吡酯组的总体有效率,分别为76.4%、81.31%、96.31%,而且P<0.05,具有统计学意义。在不良反应发生率上,P>0.05,没有统计学意义。结论:丙戊酸钠联合托吡酯在小儿癫痫的临床治疗当中具有十分显著的效果,明显优于其他单一类药物的治疗方法,所以值得推广。
Objective: To study the clinical effect of combination of sodium valproate and topiramate in the treatment of small epilepsy, and provide references for the treatment of epilepsy in children. Methods: A total of 168 children with epilepsy diagnosed in a hospital from March 2011 to March 2012 were randomly divided into three groups: sodium valproate group, topiramate group and sodium valproate Topiramate group. Patients given sodium valproate sodium valproate initial dose of about 10mg / (kg · d) about 3 times a day, and then gradually increase the dose, but not more than 40mg / (kg · d), the number of Unchanged; topiramate given to children in the topiramate group, the initial dose of 0.75mg / (kg · d), and then increase the dose, maintained at about 6mg / (kg · d), taking twice daily; sodium valproate combined with topiramate group The dosage and method of administration are the same as above. Results: The total effective rates of sodium valproate, topiramate group and sodium valproate combined with topiramate group were 76.4%, 81.31% and 96.31%, respectively, P <0.05 was statistically significant. In the incidence of adverse reactions, P> 0.05, no statistical significance. Conclusion: Sodium valproate combined with topiramate has a very significant effect in the clinical treatment of children with epilepsy, which is obviously superior to the treatment of other single drugs, so it is worth popularizing.