目的　探讨西拉普利对脑梗塞伴高血压患者日常生活能力及认知功能的影响。方法　将 42例脑梗塞伴高血压患者随机分为西拉普利治疗组 2 2例和常规治疗组 2 0例。西拉普利组给予一平苏 2 .5mg～ 5mg,每日一次 ;常规治疗组给予心痛定和 /或利尿剂治疗。两组均行运动治疗、作业治疗及神经营养 ,治疗过程中每日两次测血压 ,在治疗前及治疗 6周后采用简式Fugl Meyer评估及Barthel指数分别评定肢体运动功能及日常生活能力(ADL) ,采用简明精神状态检查 (MMSE)评估认知功能。结果　两组降压显效率及有效率无显著性差异 ,但西拉普利治疗组血压波动较小。与常规组比较 ,治疗组日常生活能力评分增高显著 (P <0 0 5 ) ,且下肢运动功能恢复明显。治疗组认知功能评分与常规组比较无统计学差异 ,但治疗组定向力及记忆力改善明显优于常规组 (P <0 0 5 )。结论　西拉普利降压效果稳定可靠 ,可改善脑梗塞伴高血压患者日常生活能力及认知功能 Objective To investigate the effects of cilazapril on daily living ability and cognitive function in patients with cerebral infarction and hypertension. Methods Forty-two patients with cerebral infarction and hypertension were randomly divided into two groups: cilostazol group (n = 22) and routine treatment group (n = 20). Cilazapril group given a Ping Su 2 .5mg ~ 5mg, once daily; conventional treatment group given nifedipine and / or diuretic treatment. Exercise therapy, neurotrophic therapy and exercise therapy were performed in both groups. Blood pressure was measured twice a day during treatment. Fugl Meyer assessment and Barthel index were used before and after 6 weeks of treatment to assess limb motor function and daily living ability ADL), cognitive function was assessed using concise mental state examination (MMSE). Results There was no significant difference between the two groups in the effective rate of hypotension and hypotension, but the corticosteroid group had less fluctuation of blood pressure. Compared with the conventional group, the score of daily living ability of the treatment group increased significantly (P <0 05), and the motor function of lower limb recovered obviously. There was no significant difference between the two groups in cognitive function score and conventional group, but the improvement of directional force and memory in the treatment group was significantly better than that in the conventional group (P <0.05). Conclusion Cilazapril is stable and reliable in lowering blood pressure, improving the daily living ability and cognitive function of patients with cerebral infarction and hypertension