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美《新英格兰医学杂志》第30卷第1期(1979年7月15日)第26页报道:多价肺炎双球菌疫苗最近已应用于婴儿、儿童及成人。对于预防正常成人的肺炎双球菌感染来说,疫苗安全、有免疫力并有保护作用。不过,疫苗不能预防包括各种血清型肺炎双球菌的感染,病人对某一种特异型的反应常常得不到保护。在疫苗准许使用后不久,就有关于失败病例的报道。本文作者叙述了患镰状细胞贫血症的儿童在接种14价肺炎双球菌疫苗后发生肺炎双球菌脓毒症或脑膜炎(或二者兼有)的情况。此疫苗不能保护患镰状细胞症的儿童免于肺炎双球菌感染,故具有重要的治疗意义。因此,本文作者再次评价了疫苗及青霉素在预防这类病人感
The New England Journal of Medicine Volume 30, Number 1 (July 15, 1979) Page 26 REPORT: The multivalent pneumococcal vaccine has recently been applied to infants, children and adults. The vaccine is safe, immune and protective for the prevention of pneumococcal infections in normal adults. However, vaccines can not prevent infections including various serotypes of pneumococci, and patients often fail to be protected against a particular type of response. Shortly after the vaccine is approved for use, there are reports of failed cases. The authors describe the occurrence of pneumococcal sepsis or meningitis (or both) in children with sickle cell anemia after vaccination with 14-valent pneumococcal vaccines. This vaccine can not protect children suffering from sickle cell disease from pneumococcal infection, it has an important therapeutic significance. Therefore, the author reevaluates the vaccine and penicillin in preventing such patients