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哮喘是一种十分常见的疾病,表现为突然发作的气促,严重者可因呼吸困难而危及生命.引起哮喘的原因很多,有感染、花粉、异体蛋白等.近年来通过医学专家的多项研究表明,胃食管反流性疾病(GERD)是引起哮喘的主要原因之一.临床观察告诉人们,当病人有哮喘症状而用一两种抗哮喘药物治疗无效时,就应疑有胃食管反流性疾病.某些病人在接受抗酸反流治疗后,可减轻或消除哮喘症状,同时可减少抗哮喘药物的应用.大量的临床资料表明,胃食管反流性疾病和哮喘共存,有80%左右的哮喘患者有食管下段括约肌松驰、收缩乏力等异常.判断胃食管反流引起哮喘的线索有:哮喘发生于成年人;在餐后、躺下或运动时哮喘发作和加重;夜间或平卧时哮喘发作和加重.胃食管反流引起哮喘的作用机制,第一是微量或大量吸入胃内容物,引起化学性肺炎.因为仰卧睡眠易发生酸性物质吸入呼吸道,所以与胃食管反流相关的哮喘最常见于夜间发作.第二是食管粘膜受体兴奋引起迷走神经介导的支气管痉挛,反流清除时间延长常导致食管
Asthma is a very common disease, manifested as sudden onset of shortness of breath, severe cases can be life-threatening due to breathing difficulties.Acute asthma caused by many, there are infections, pollen, foreign proteins, etc. In recent years through a number of medical experts Studies have shown that gastroesophageal reflux disease (GERD) is one of the main causes of asthma.Clinical observations tell people that when patients with asthma symptoms and one or two anti-asthma drugs ineffective, it should be suspected gastroesophageal Fluid disease Some patients after receiving acid reflux therapy can reduce or eliminate the symptoms of asthma and reduce the use of anti-asthma drugs.Many clinical data show that gastroesophageal reflux disease and asthma coexist with 80 About% of patients with asthma have lower esophageal sphincter relaxation, weakness and other abnormalities to determine the gastroesophageal reflux caused asthma clues: asthma occurs in adults; after the meal, lie down or exercise asthma attack and aggravate; night or Supine asthma attack and aggravate. Gastroesophageal reflux caused asthma mechanism of action, the first is micro or large inhalation of stomach contents, causing chemical pneumonia. Because of prone sleep acidic acidic substances Into the respiratory tract, it is associated with gastroesophageal reflux asthma is most common in the night attack. The second is the esophageal mucosa excited vagus nerve receptor-mediated bronchospasm, reflux often leads to prolonged esophageal clearance