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目的分析与探讨25-羟维生素D水平在儿童过敏性疾病中的表达,并研究其对疾病治疗的指导价值及评价。方法将2014年4月-2016年4月经广州医科大学附属第三医院荔湾医院检查临床确诊后进行治疗的93例过敏性疾病患儿选为观察组,随机选取93例健康儿童为对照组,比较两组儿童25-羟维生素D水平。经过系统治疗后,观察并评价过敏性疾病儿童不同病情控制期的25-羟维生素D水平差异。结果观察组患儿25-羟维生素D(25.56±9.33)mmol/L明显低于对照组儿童(45.72±12.28)mmol/L,差异有统计学意义(P<0.05)。经过治疗后,观察组患儿中完全控制组25-羟维生素D水平高于部分控制组及无有效控制组,疾病控制期不同控制水平患儿血清25-羟维生素D水平差异有统计学意义(P<0.05)。结论 25-羟维生素D水平与儿童过敏性疾病的表达相关,有助于疾病的诊断。且随着病情的控制,25-羟维生素D水平明显增高,对疾病治疗具有较优的指导价值,有助于病情及治疗效果的监测。
Objective To analyze and explore the expression of 25-hydroxyvitamin D in children with allergic diseases and to study its guiding value and evaluation of disease treatment. Methods From April 2014 to April 2016, 93 children with allergic diseases who were clinically diagnosed and checked by Liwan Hospital, Third Affiliated Hospital of Guangzhou Medical University were selected as observation group and 93 healthy children were selected as control group randomly. Two groups of children 25-hydroxy vitamin D levels. After systematic treatment, observation and evaluation of children with allergic diseases in different disease control period 25-hydroxy vitamin D levels. Results The 25-hydroxyvitamin D (25.56 ± 9.33) mmol / L in the observation group was significantly lower than that in the control group (45.72 ± 12.28 mmol / L, P <0.05). After treatment, the observation group of children with complete control group 25-hydroxy vitamin D levels were higher than some of the control group and no effective control group, the disease control of children with different levels of control serum 25-hydroxy vitamin D levels were statistically significant ( P <0.05). Conclusion 25-hydroxyvitamin D is associated with the expression of allergic diseases in children, which is helpful for the diagnosis of diseases. And with the disease control, 25-hydroxyvitamin D levels were significantly increased, the disease treatment has a better guide value, help to monitor the condition and treatment effect.