Selby 等报道用大剂量苯丙氨酸氮芥(HDM)静脉给药治疗多发性骨髓瘤(MM)的经验。41例先前未经治疗的 MM 有78%治疗有效,27%达到完全缓解(CR)。CR 中位数时间为19个月,但仅有1例病人在2年后仍处于 CR 阶段。作者用同样的 HDM 治疗高危性 MM。对2例用HDM 后已达 CR 者,作者试图用第二疗程 HDM,接着进行自身骨髓移植(ABMT)以维持病人 CR。此2 Selby et al. Reported on the experience of intravenous administration of high-dose melphalan (HDM) to multiple myeloma (MM). Of the 41 previously untreated MMs, 78% were treated effectively and 27% achieved complete remission (CR). The median time to CR was 19 months, but only 1 patient remained in CR after 2 years. The author used the same HDM to treat high-risk MM. For two patients who had already achieved CR after HDM, the authors attempted to use a second course of HDM followed by autologous bone marrow transplantation (ABMT) to maintain CR. This 2