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目的了解广州市妇女感染人乳头瘤病毒(Human Papillomavirus,HPV)的型别分布情况,为宫颈癌的预防和疫苗的研制提供科学依据。方法由医生采集阴道分泌物标本,采用表面等离子谐振法进行基因分型,用Excel2003整理数据,SPSS17.0进行统计分析。结果 HPV感染阳性的检出率为18.8%(87/464),其中高、低危型的检出率分别为14.2%(66/464)与6.9%(32/464),高危型中主要为HPV18,51感染,低危型中主要为HPV44感染。18岁~33岁,34岁~49岁和>50岁组HPV高危型检出率分别为12.2%,17.3%、和30.8%,差别没有统计学意义(χ2=5.04,P=0.080)。低危型感染、多重感染等感染率各年龄组差别均没有统计学意义。结论 HPV18、51是广州市高危型HPV感染的主要型别,HPV 44是低危型HPV感染的主要感染型别,针对广州地区疫苗的开发应该关注HPV18、44、51等型别的感染。
Objective To understand the type distribution of human papillomavirus (HPV) in Guangzhou and to provide a scientific basis for the prevention of cervical cancer and the development of vaccine. Methods Vaginal secretions specimens were collected by doctors and genotyped by surface plasmon resonance method. The data were sorted by Excel2003 and SPSS17.0 was used for statistical analysis. Results The positive rate of HPV infection was 18.8% (87/464). The detection rates of high and low risk type were 14.2% (66/464) and 6.9% (32/464), respectively. The prevalence of HPV infection was HPV18,51 infection, low-risk type mainly HPV44 infection. The detection rates of HPV high risk genotypes were 12.2%, 17.3%, and 30.8% respectively in 18-33 years old, 34-49 years old and> 50 years old group, with no significant difference (χ2 = 5.04, P = 0.080). Low-risk infection, multiple infections and other infection rates in different age groups were not statistically significant. Conclusion HPV18 and 51 are the main types of high-risk HPV infection in Guangzhou. HPV44 is the major infection type of low-risk HPV infection. For the development of vaccine in Guangzhou area, HPV18, 44 and 51 should be considered.