该文应用全国出生缺陷预防研究(一项人群病例对照研究)的数据验证以前报道的降压药与心血管畸形之间的关系,并探讨两者之间是否有其他关系。方法:1997-2003年在美国10个州通过出生缺陷监测系统确定了5021例心血管畸形儿作为病例组。随机选择同地区经出生证明或出院证明证实没有 This article uses data from the National Birth Defects Prevention Study (a population-based case-control study) to validate the previously reported relationship between antihypertensive drugs and cardiovascular malformations and to explore whether there is any other relationship between the two. Methods: From 1997 to 2003, 5021 cardiovascular malformation children were identified as the case group in 10 U.S. states through birth defect monitoring system. Randomly selected the same area with a birth certificate or a certificate of discharge confirmed no