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Manufacturing industry is an important symbol which weighs a local economy comprehensive strength and modernized level, and a mighty manufacturing industry is a reliable guarantee which realizes the industry modernization.The manufacturing industry in eastern coastal provinces and cities of China, including Shandong, Jiangsu Zhejiang, Shanghai and Guangdong, holds a quite high proportion, and is competitive.But as to the interior, the manufacturing industry competitiveness of five provinces and cities actually has obviously gradient difference.The concrete profession's competitiveness also has the characteristic respectively.This paper analyzes the competitiveness of manufacturing industry in five provinces and cities by the shift-share analysis, obtains a conclusion that Shandong and Zhejiang have the competitive advantage in the traditional manufacturing industry, that Jiangsu's and Guangdong's competitiveness lies in capital, technology-intensive industry, but that Shanghai manufacturing industry's competitive advantage is not obvious, and then proposes strategy to promote the manufacturing industry in the eastern coastal provinces and cities.